Does testosterone substitute therapy (TRT) increase the danger of heart attack or stroke in men? A brand new study suggests no, though with some caveats. Researchers enrolled 5,246 men ages 45 to 80 with testosterone levels below 300 nanograms per deciliter (ng/dL). (Normal levels range from 300 to 1,000 ng/dL.) More than 50% had existing heart problems, while others had diabetes, hypertension, smoking, and lipid imbalances (total cholesterol, low-density lipoprotein , high-density lipoprotein, and triglycerides).
For a median of twenty-two months, the lads applied one gel to their skin every day. For half the lads, the gel was placebo (inactive). For others, it incorporates enough testosterone to keep up hormone levels between 350 and 750 ng/dL. At three-year follow-up, the researchers found no difference within the rates of heart attack, stroke, or death from cardiovascular problems between the TRT and placebo groups. However, compared with men who took a placebo, TRT users had a better risk of atrial fibrillation (an irregular heartbeat that may increase the danger of stroke and heart failure) and pulmonary embolism (during which a blood clot travels to the lungs). is) was more more likely to occur. (blocks artery and blood flow).