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Low-dose aspirin therapy has been shown to assist prevent heart attacks, but a study within the August 4, 2018 issue of The Lancet Suggests that men who weigh greater than 154 kilos may have a better dose. Researchers analyzed 10 trials that evaluated day by day aspirin therapy for heart problems prevention in 120,000 men and ladies. Study participants had no history of heart or vascular disease. The researchers found that low-dose aspirin — 75 to 100 milligrams per day — was related to a reduced risk of heart attack and stroke in each men and ladies weighing lower than 154 kilos.
However, there was no significant effect for heavy patients. (About 80 percent of the lads within the study were on this group.) The reason? The researchers hypothesized that obese people even have higher levels of esterase, an enzyme that reduces the provision of aspirin within the body.
This doesn’t mean that obese people cannot profit from aspirin therapy. It could also be that they need more food. However, we’d like additional research to find out whether higher doses of aspirin are effective in obese individuals and to find out the best dose. If a better dose is required, there may be a trade-off, as higher doses of aspirin may increase the chance of bleeding.
